Concurrent Biologics Registry

A Clinical Reference for Concurrent Biologic Therapy

Published cases of concurrent biologic therapy are scattered across journals and specialties, and much clinical experience is never published. The registry brings both into one searchable record, so decisions made one case at a time can draw on what has already been reported.

Combination Matrix

October 2026

Combination matrix of the 6 most reported biologics in the registry. The most reported pair is Dupilumab plus Omalizumab with 51 patient cases.

Most reported: Dupilumab + Omalizumab (51 cases)

Six most reported biologics shown. Empty cells are combinations with no registry cases yet.

Explore the full matrix

224

Patient Cases

59

Combinations

70

Diagnoses

64

Published Sources

The Problem

Clinical Information Is Fragmented

Concurrent biologic use is an increasingly common clinical consideration, yet reported experience with it remains scattered.

There is no shared record of concurrent biologic therapy cases across specialties. Clinicians decide one case at a time, on partial information.

In the clinic

Concurrent therapy is a growing consideration

  • Patients with overlapping immune-mediated conditions
  • Disease refractory to single-agent therapy
  • Decisions spanning gastroenterology, rheumatology, and dermatology

In the literature

Published experience is hard to find

  • Isolated case reports and small case series
  • Extrapolation from single-agent data
  • No single place to review reported outcomes and adverse events

The Solution

The First Registry for Concurrent Biologic Therapy

A curated record of published and clinician-contributed cases across immune-mediated inflammatory diseases.

  • Gathered in one place

    Cases that would otherwise stay isolated in single publications, or go unreported, are gathered in one place and can be searched by combination, diagnosis, and region.

  • International

    Published literature and clinician submissions from sites worldwide, across specialties.

  • Linked to the source

    Every published case comes from a peer-reviewed source in the registry's reference list, with a DOI link to the original article.

Isolated case reports and unreported clinical experience are consolidated into one structured registry.

How It Works

Two Sources, One Record

Published cases and unpublished clinical experience enter through two complementary pathways and pass a single quality review.

Source

Published literature

Case reports, case series, and observational studies, extracted into a standardized format.

Source

Clinical submissions

Cases submitted by healthcare professionals through a structured template that collects no direct identifiers.

Submit a case
Review

Quality review

Every case is checked for completeness, clinical plausibility, and consistency before inclusion.

Registry

One open record

Searchable and freely accessible to clinicians worldwide.

Clinical scope

What each case records

The registry accepts cases across immune-mediated inflammatory diseases and records the same structured variables for each one, with no direct identifiers.

Inclusion criterion

One biologic plus a second biologic or a targeted oral therapy makes one registry case.

At least two concurrent advanced therapies, at least one of which is a biologic. Conventional systemic immunosuppressants are recorded separately as concomitant therapy.

Recorded for every case

  • Demographics

    Age bracket and sex

  • Agents used

    Biologics and targeted oral therapies

  • Primary diagnosis

    Coded to ICD-10

  • Duration

    Length of concurrent therapy

  • Concomitant medications

    Conventional systemic agents

  • Disease activity

    Validated measures, where available

  • Clinical outcome

    On a standardized scale

  • Adverse events

    Observed during treatment

No direct patient identifiers are collected at any stage.

Conditions

Immune-mediated inflammatory diseases across specialties.

Psoriasis & Psoriatic ArthritisAtopic DermatitisHidradenitis SuppurativaChronic Spontaneous UrticariaInflammatory Bowel DiseaseRheumatoid ArthritisAxial SpondyloarthritisSystemic Lupus ErythematosusAutoimmune Blistering Diseases+ many more

Biologics

Any biologic agent, recorded by class or individual molecule.

TNF-alpha InhibitorsIL-17 InhibitorsIL-23 InhibitorsIL-12/23 InhibitorsIL-4/IL-13 Pathway BlockersIL-6 Receptor InhibitorsIL-5 InhibitorsAnti-IgE AgentsB-cell Depleting TherapiesFcRn Inhibitors+ many more

Targeted oral therapies

Targeted synthetic agents and oral targeted peptides, recorded alongside biologics.

JAK InhibitorsTYK2 InhibitorsPDE4 InhibitorsBTK InhibitorsSYK InhibitorsS1P Receptor ModulatorsROCK2 InhibitorsOral IL-23 Receptor Antagonists+ many more

By the Numbers

Registry at a Glance

A summary of reported cases of concurrent biologic therapy.

224 patient cases from 64 peer-reviewed sources and clinician submissions worldwide. Data current as of October 2026.

0

Patient Cases

From peer-reviewed literature and clinician submissions

0

Unique Combinations

43 biologic pairs, 16 biologic + oral

0

Outcome Reported

of 224 cases

0

Adverse Event Reported

of 190 cases with status reported

0

Concomitant Systemic Therapy

of 224 cases

Registry figures describe reported cases only. They are not estimates of effectiveness, safety, or how often outcomes or adverse events occur, and they should not be used to compare combinations. Published and voluntarily submitted cases tend to over-represent good outcomes. Treatment decisions remain with the treating clinician.

Drug Combinations

Therapy Combination Explorer

Case-level details can be viewed by selecting any combination: biologic pairs by molecule or by drug class, biologic plus targeted oral therapy combinations, or the ranked list of every combination.

Filter the data

Showing 224 of 224 cases.

Diagnosis

Region

Combination

Biologic

Oral therapy

Therapy combination patient counts

n = 152 cases across 43 biologic pairs

Patient case counts for therapy combinations, viewable as a matrix of biologic pairs by molecule or by drug class, as a matrix of biologics against targeted oral therapies, or as a ranked list of every combination. Selecting a populated cell or list entry opens a case-level table below, listing the diagnosis, age, sex, duration, outcome, adverse event, and source of each case. The Source column states whether a case is published or clinician-contributed.

Showing 18 of 26 biologics, those with two or more cases.

Dupilumab
Omalizumab
Ustekinumab
Guselkumab
Rituximab
Infliximab
Adalimumab
Risankizumab
Secukinumab
Etanercept
Mepolizumab
Vedolizumab
Golimumab
Tildrakizumab
Evolocumab
Tralokinumab
Anifrolumab
Benralizumab
Dupilumab
Omalizumab
Ustekinumab
Guselkumab
Rituximab
Infliximab
Adalimumab
Risankizumab
Secukinumab
Etanercept
Mepolizumab
Vedolizumab
Golimumab
Tildrakizumab
Evolocumab
Tralokinumab
Anifrolumab
Benralizumab

Fewer
More

72 biologic + targeted oral therapy cases shown separately.

Case Mix

Registry Coverage

Where reported cases come from and which diagnoses they involve.

Geographic distribution

n = 224

Geographic distribution of 224 patient cases by macro region: North America 131 (58%), Europe 46 (21%), Asia 30 (13%), Oceania 16 (7%), South America 1 (0%).

Cases contributed across 5 continents. Selecting a bar filters the data sections by region.

Diagnosis landscape

n = 224

Diagnosis groups across 224 patient cases: Psoriasis (L40) 85, Atopic dermatitis (L20) 84, Chronic urticaria (L50) 48, Inflammatory bowel disease (K50/K51) 46, Asthma (J45) 23, Spondyloarthritis (M45/M46) 19, Bullous pemphigoid (L12.0) 15, Hidradenitis suppurativa (L73.2) 4, Granulomatous skin disorders (L92) 4, Rheumatoid arthritis (M05/M06) 2, Other diagnoses 36.

Groups are not mutually exclusive; a case may carry several diagnoses. Selecting a bar filters the data sections by diagnosis.

Clinical Outcomes

Reported Outcomes and Demographics

Outcome categorization and demographic distribution across registry cases.

Outcome category

n = 224

  • Complete Remission (22)
  • Well Controlled (62)
  • Improvement (73)
  • Mixed (28)
  • No Response (8)
  • Not Reported (31)
Outcome categories across 224 patient cases: Complete Remission 22, Well Controlled 62, Improvement 73, Mixed 28, No Response 8, Not Reported 31.

Age distribution

n = 224

Age distribution of 224 patient cases stacked by sex. 0-9: 1 female, 0 male, 0 not recorded; 10-19: 6 female, 7 male, 1 not recorded; 20-29: 17 female, 14 male, 4 not recorded; 30-39: 23 female, 14 male, 1 not recorded; 40-49: 25 female, 14 male, 3 not recorded; 50-59: 11 female, 25 male, 6 not recorded; 60-69: 15 female, 13 male, 1 not recorded; 70-79: 8 female, 7 male, 0 not recorded; 80+: 2 female, 4 male, 0 not recorded; N/A: 0 female, 0 male, 2 not recorded.

Sex was not recorded for 18 cases, shown in slate.

Treatment Patterns

Treatment Duration and Agents

Duration of concurrent therapy and how often each agent appears in registry cases.

Treatment duration

n = 224

Treatment duration across 224 patient cases by band: <3m: 15, 3-5m: 56, 6-11m: 59, 12-17m: 33, 18-23m: 14, >24m: 29, N/A: 18.

18 cases without reported duration, shown in slate.

Most frequently reported agents

n = 224 cases, two agents each

Most frequently reported agents across 224 patient cases, two agents per case, biologics and targeted oral therapies alike. Top agents: Dupilumab (biologic) in 99 cases, Omalizumab (biologic) in 74 cases, Risankizumab (biologic) in 31 cases, Upadacitinib (targeted oral therapy) in 31 cases, Ustekinumab (biologic) in 28 cases, Guselkumab (biologic) in 25 cases, Deucravacitinib (targeted oral therapy) in 22 cases, Adalimumab (biologic) in 19 cases, Tofacitinib (targeted oral therapy) in 19 cases, Infliximab (biologic) in 14 cases, plus 21 additional agents.

Adverse Events

Reported Adverse Events

Adverse events reported for each therapy combination. All reported events are shown regardless of severity or attribution.

Adverse events by combination

n = 224

Number of reported cases with and without a reported adverse event for each therapy combination, across 224 patient cases. Dupilumab + Omalizumab (51): 9 with and 42 without an adverse event; Risankizumab + Upadacitinib (21): 17 with and 4 without an adverse event; Dupilumab + Guselkumab (16): 1 with and 15 without an adverse event; Omalizumab + Rituximab (10): 5 with and 5 without an adverse event; Brodalumab + Deucravacitinib (10): 0 with and 0 without an adverse event, 10 not individually reported; All other combinations (116): 10 with and 82 without an adverse event, 24 not individually reported.

Counts of reported cases only. Not estimates of effectiveness, safety, or frequency, and not comparable between combinations. All reported events are shown regardless of severity or attribution; no inference of causality is implied. Combinations with fewer than 10 cases are pooled. 34 cases come from series that did not report adverse events for individual patients; they are shown in slate and are not counted as with or without an event.

Independent and open access

No industry funding. No paywalls.

The Concurrent Biologics Registry is provided free of charge to clinicians worldwide and operates without pharmaceutical industry funding or compensation.

  • Open access
  • Independent
  • No industry funding

Disclosure statement

Applies to all content

Registry operationOperated by CMSD and maintained by Dermi on a volunteer basis
Volunteer
Access to data and visualizationsNo registration, login, or payment required
Free
Pharmaceutical industry fundingNo drug manufacturer supports this work
None
Sponsorship or compensationNo payment from manufacturers or trade groups
None
Industry influence on scope, methodology, or contentEditorial decisions are made independently
None

Trust and transparency

Built on rigor, designed for openness

A freely accessible quality assurance and practice improvement resource that consolidates published and clinician-submitted cases into a single repository.

No direct identifiers by design

Only a minimal set of structured clinical variables is captured: age band, sex, disease category, agents, and outcomes.

Never collected

  • No names
  • No dates of birth
  • No treatment dates
  • No record numbers

Open-access data

The full registry and every visualization are available to anyone, at the point of care.

Access requirements

  • No registration
  • No login
  • No payment

Structured quality review

Every case is reviewed before inclusion so the data stay accurate and clinically credible.

Checked for

  • Completeness
  • Clinical plausibility
  • Consistency

International contributions

Cases come from published literature and from clinician submissions worldwide.

Sourced from

  • Peer-reviewed literature
  • Clinician submissions
  • International sites

Common Questions

Frequently Asked Questions

Answers to common questions about the Concurrent Biologics Registry, its data, and how to participate.

Concurrent biologic therapy refers to the simultaneous use of two or more advanced therapies in a single patient, at least one of which is a biologic. This typically arises when a patient has multiple immune-mediated conditions, each requiring a distinct agent with a different mechanism of action, or when disease remains refractory to a single agent.
Yes. Targeted synthetic agents such as JAK, TYK2, PDE4, BTK and S1P inhibitors, and oral targeted peptides such as icotrokinra, are recorded alongside biologics and count toward the concurrent therapy requirement. The inclusion criterion is mechanism-based rather than modality-based: an oral agent acting on the IL-23 receptor is pharmacologically comparable to a monoclonal antibody acting on the same pathway, and excluding it would make molecular size a scientific inclusion criterion. Each case must still record at least one biologic. Conventional systemic immunosuppressants such as methotrexate, ciclosporin and systemic corticosteroids are recorded separately as concomitant therapy rather than as advanced therapies.
Validated instruments can be recorded as absolute scores at baseline and follow-up, with a relative follow-up interval. The catalogue covers psoriatic disease (PASI, BSA, sPGA, DAPSA, cDAPSA, MDA, PASDAS, LEI, SPARCC), axial disease (ASDAS, BASDAI, BASFI), rheumatoid arthritis (DAS28, CDAI, SDAI), atopic dermatitis (EASI, SCORAD, POEM, vIGA-AD), urticaria (UAS7, UCT), hidradenitis suppurativa (IHS4, Hurley, HiSCR50), inflammatory bowel disease, autoimmune bullous disease, lupus, and cross-disease measures such as DLQI. Measures relevant to the diagnoses already selected are offered first. Recording them is optional, because retrospective and literature-derived cases frequently lack them, and completeness is reported alongside any derived figure rather than treated as absence. Percentage response criteria such as PASI 90 are deliberately not collected, because a single field cannot distinguish a ninety percent response from an absolute score of nine.
Any licensed healthcare professional managing patients on concurrent advanced therapy. Submissions are accepted from any institution worldwide and undergo structured quality review before inclusion. The registry collects structured clinical information, without direct patient identifiers, for quality assurance and practice improvement.
The registry is designed so that no direct patient identifiers are collected. The submission template captures a minimal set of structured clinical variables: age band, biological sex, disease category, biologic and targeted oral agents, duration of therapy, concomitant systemic therapy, disease activity scores, clinical outcomes, adverse events, care setting, and continent-level region. Follow-up timing is recorded only as a relative interval, such as week 24. Names, initials, dates of birth, treatment or assessment dates, medical record numbers, addresses, and other direct identifiers are never requested, and free-text fields must not contain identifying details. Every submission is screened before inclusion.
The registry draws from two complementary sources. Published literature: case reports, case series, and observational studies are identified through structured literature searches, extracted, and catalogued in a standardized format. Clinician submissions: cases are entered through a structured template that collects no direct identifiers and are reviewed before inclusion.
Clinicians can look up a combination and review each case recorded for it: diagnoses, duration of therapy, outcome, and any adverse events, with a reference list linking to the original publications. The registry does not make treatment recommendations and is not a pharmacovigilance (safety-monitoring) system. Serious adverse reactions should be reported to Health Canada through Canada Vigilance, or to the relevant national regulator.
No. The registry shows what has been reported for each combination, so clinicians can review that experience in one place. Because most cases come from case reports, small case series, and voluntary submissions, the figures cannot establish effectiveness or safety, estimate how often outcomes or adverse events occur, or compare one combination with another. Treatment decisions remain with the treating clinician.

Literature

References

64 peer-reviewed sources, 2005–2026

  1. Response of chronic refractory psoriasis vulgaris with urticaria to combined secukinumab and omalizumab: A case report and review of the literature

    Abdelmaksoud, A., Temiz, S. A., Daye, M., Yavuz, S., Wollina, U., Lotti, T., & Dursun, R.

    Journal of Cosmetic Dermatology202322(4), 1416–1418

  2. Successful dual targeted therapy with upadacitinib and risankizumab in psoriatic arthritis, uveitis and alopecia areata

    Adell, N., Notario, J., Narváez, J., & Berbel-Arcobé, L.

    Joint Bone Spine202693(2), 106015

  3. Efficacy and safety of dual-targeted therapy with tofacitinib and TNF inhibitors in refractory spondyloarthritis: a case series from a tertiary care center

    Agrawal, A., Yadav, S. S., & Balakrishnan, C.

    Therapeutic Advances in Musculoskeletal Disease202618, 1759720X261449890

  4. Combination treatment with monoclonal antibodies: Dupilumab and ustekinumab for the treatment of severe atopic dermatitis and Crohn disease

    Alegre-Bailo, A., Sánchez-Gilo, A., Gonzalo González, I., & Vicente Martín, F. J.

    Australasian Journal of Dermatology202465(1), 63–66

  5. A 17-Year-Old Male Adolescent With Refractory Crohn's Disease Managed With Upadacitinib and Risankizumab Combination Therapy: A Case Report and Review of Current Evidence

    Alhashemi, M., & Shehab, M.

    American Journal of Case Reports202627, e950174

  6. A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report

    Antolini, S., Scagliosi, G., Veliaj, O., Carletto, A., Fracassi, E., & Gisondi, P.

    SAGE Open Medical Case Reports202513, 2050313X251352160

  7. Dual biologic therapy with Omalizumab and Dupilumab for refractory atopic disease

    Arasu, A., Sharma, N., Yazdabadi, A., & Sladden, M.

    Australasian Journal of Dermatology202263(1), 110–111

  8. Combined biologic therapy for the treatment of psoriasis and psoriatic arthritis: A case report

    Babalola, O., Lakdawala, N., & Strober, B. E.

    JAAD Case Reports20151(1), 3–4

  9. Combination Therapy With Upadacitinib and Dupilumab for Severe Atopic Dermatitis

    Barrutia-Etxebarria, A., Lopez Martinez, J., Escribano De La Torre, R. M., Heras Gonzalez, S., Arrue Michelena, I., Gimeno Castillo, J., Berrueta Navascues, A., Gonzalez Perez, R., & Fatsini Blanch, V.

    International Journal of Dermatology202564(9), 1731–1734

  10. A retrospective review of dupilumab and psoriasis biologic combination therapy

    Barry, K., Zancanaro, P., Casseres, R., Dumont, N., & Rosmarin, D.

    Journal of Dermatological Treatment202132(4), 438–439

  11. Two Track Biologic Therapy for Concurrent Chronic Spontaneous Urticaria and Psoriasis Vulgaris in One Patient

    Benko, M., Hrvatin Stancic, B., & Lunder, T.

    Actas Dermo-Sifiliográficas2022113(10), 995–996

  12. Landmarks for dual biological therapy in inflammatory bowel disease: lesson from two case reports of vedolizumab in combination with ustekinumab

    Biscaglia, G., Piazzolla, M., Cocomazzi, F., Melchionda, G., De Cata, A., Bossa, F., Palmieri, O., & Andriulli, A.

    European Journal of Gastroenterology & Hepatology202032(12), 1579–1582

  13. Navigating the Misdiagnosis of Pityriasis Rubra Pilaris and Successful Treatment With Guselkumab: A Case Report of Dual Biologic Therapy

    Bongfeldt, D., & Martinez-Cabriales, S.

    Cureus202517(12), e98267

  14. Dual biologics therapy in a patient with severe asthma and chronic urticaria: A case report and review of the literature

    Bostan, O. C., Karakaya, G., Kalyoncu, A. F., & Damadoglu, E.

    Journal of Asthma202461(3), 260–264

  15. Efficacy and Safety of Upadacitinib and Vedolizumab Combination for Refractory Orofacial Granulomatosis Associated with Panenteric Crohn's Disease: A Case Report

    Campigotto, M., Priotto, F., Tonello, C. F., Monica, F., & Crocè, S. L.

    Reports20258(2), 37

  16. Dual biologic therapy in a patient with severe asthma and other allergic disorders

    Caskey, J. R., & Kaufman, D.

    BMJ Case Reports202114(5), e242211

  17. The efficacy of tofacitinib combined with bDMARDs in the treatment of ankylosing spondylitis patients with inadequate response to bDMARDs: a retrospective study

    Chang, J., & Wang, G.

    BMC Rheumatology20248(1), 3

  18. Successful treatment of hidradenitis suppurativa in the setting of Crohn disease with combination adalimumab and ustekinumab

    Cline, A., & Pichardo, R. O.

    Dermatology Online Journal201925(9), Article 13030/qt0hw2w4nr

  19. Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping

    Cornman, H. L., Alphonse, M. P., Dykema, A., Kollhoff, A. L., Lee, K. K., Manjunath, J., Ma, E. Z., Parthasarathy, V., Deng, J., Pritchard, T., Kambala, A., Marani, M., Parr, K. A., Mohammed, J. P., Kwatra, M. M., Bream, J. H., Ho, W. J., & Kwatra, S. G.

    Scientific Reports202515(1), Article 1298

  20. Combination Biologic Treatment of Refractory Psoriasis and Psoriatic Arthritis

    Cuchacovich, R., Garcia-Valladares, I., & Espinoza, L. R.

    The Journal of Rheumatology201239(1), 187–193

  21. Omalizumab and adalimumab: a winning couple

    Diluvio, L., Vollono, L., Zangrilli, A., Manfreda, V., Prete, M. D., Massaro, A., Modica, S., Greco, E., Bianchi, L., & Campione, E.

    Immunotherapy202012(18), 1287–1292

  22. Coesisting inflammatory skin diseases: Tildrakizumab to control psoriasis and omalizumab for urticaria

    Diluvio, L., Pensa, C., Piccolo, A., Lanna, C., Bianchi, L., & Campione, E.

    Dermatologic Therapy202235(4), e15359

  23. Dual-Targeted Therapy with Risankizumab and Upadacitinib in Medically Complex Crohn's Disease

    Fear, E. N., McDonald, B. D., Kennedy, M. S., Mathew, A. J., McMillan, R. H., Fine, Z. D., McDermott, A. R., Choi, D., Kellar, A., & Rubin, D. T.

    Crohn's & Colitis 36020268(2), otag049

  24. The use of dual biologic therapy for the management of recalcitrant psoriasis

    Finnegan, P., Murphy, M., & Bourke, J.

    JAAD Case Reports202447, 93–95

  25. Case Series: Combination of dupilumab and omalizumab as a way to reduce dupilumab-associated adverse events in severe atopic dermatitis

    Fomina, D. S., Mukhina, O. A., Sedova, E. L., Lebedkina, M. S., Bobrikova, E. N., Karaulov, A. V., Lysenko, M. A., & Renz, H.

    Frontiers in Allergy20266, Article 1696897

  26. Combined biologic treatment in patient with chronic spontaneous urticaria and Crohn's disease

    García Martínez, A., Lobato de la Sierra, M. P., & Castro Aguilar-Tablada, T.

    Gastroenterología y Hepatología (English Edition)202548(1), Article 502213

  27. Combined treatment with omalizumab and etanercept in a patient with chronic spontaneous urticaria and rheumatoid arthritis

    Ghazanfar, M. N., & Thomsen, S. F.

    Journal of Dermatological Treatment201930(4), 387–388

  28. Rapid food desensitization supported by omalizumab, with adjunctive dupilumab for type 2 comorbidities: A pediatric case series

    Giavina-Bianchi, P., & Giavina-Bianchi, B.

    World Allergy Organization Journal202619(4), Article 101374

  29. The Combination of Dupilumab with Other Monoclonal Antibodies

    Gisondi, P., Maurelli, M., Costanzo, A., Esposito, M., & Girolomoni, G.

    Dermatology and Therapy202213(1), 7–12

  30. Failure of response to combination therapy of adalimumab and infliximab in a recalcitrant patient of severe psoriasis and major thalassemia: A case report

    Goldust, M., Rahmatpour Rokni, G., Gupta, M., Lotti, T., & Bathaei, M.

    Clinical Case Reports20208(3), 550–552

  31. Safety and efficacy of dual tyrosine kinase 2 inhibitor and monoclonal antibody therapy for psoriasis and psoriatic arthritis

    Guénin, S., Andrews, E., & Lebwohl, M. G.

    British Journal of Dermatology2024190(3), 451–453

  32. Novel combination biologic therapy for recalcitrant psoriasis and psoriatic arthritis in a medically complex patient

    Hanna, S., Youssef, P., & Lowe, P.

    Australasian Journal of Dermatology202263(1), e63–e66

  33. Concurrent use of omalizumab and dupilumab in a 47-year-old woman with chronic spontaneous urticaria and atopic dermatitis

    Holm, J. G., Sørensen, J. A., & Thomsen, S. F.

    International Journal of Dermatology202261(5), e173–e174

  34. The safety and efficacy of dual biological therapy: Dupilumab and fremanezumab

    Honigman, A., Oo, H. P., Macdonell, R., & Kern, J. S.

    Australasian Journal of Dermatology202465(3), e63–e65

  35. Use of dual biologic therapy targeting the Th2 and Th17 axes simultaneously to treat patients with atopic dermatitis and concomitant psoriasis, psoriatic arthritis, or inflammatory bowel disease

    Hren, M. G., Guenin, S., & Khattri, S.

    Journal of the American Academy of Dermatology202491(1), 138–140

  36. Treatment of recalcitrant psoriasis and psoriatic arthritis with a combination of a biologic plus an oral JAK or TYK2 inhibitor: a case series

    Hren, M. G., & Khattri, S.

    Annals of the Rheumatic Diseases202483(10), 1392–1393

  37. Concurrent Atopic Dermatitis and Psoriasis Successfully Treated With Dual Biologic Therapy

    Kaszycki, M. A., Pixley, J. N., & Feldman, S. R.

    Cutis2023112(3), E13–E16

  38. Rituximab and Omalizumab Combination Therapy for Bullous Pemphigoid

    Le, S. T., Herbert, S., Haughton, R., Nava, J., Toussi, A., Ji-Xu, A., & Maverakis, E.

    JAMA Dermatology2024160(1), 107–109

  39. Dual Biological Therapy for Ulcerative Colitis with Intractable Pyoderma Gangrenosum

    Lee, H. C., Kwon, Y., Kim, E. S., Ahn, S., Choe, Y. H., & Kim, M. J.

    Annals of Dermatology202335(Suppl 1), S107–S111

  40. Case Report: Relapsing systemic lupus erythematosus treated with dual rituximab and anifrolumab therapy

    Lee, S., Choi, J., Benitez, S., & Lee, J.

    Frontiers in Medicine202612, Article 1727404

  41. Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series

    Lowes, M. A., Turton, J. A., Krueger, J. G., & Barnetson, R. S.

    BMC Dermatology20055(1), Article 9

  42. Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis

    Ma, L., Chen, X., Aziz, M. A. A., Chen, A., Cai, T., & Chen, S.

    Psoriasis: Targets and Therapy202515, 159–161

  43. Combination treatment with monoclonal antibodies: Secukinumab, benralizumab and dupilumab for the combined management of psoriasis and severe asthma

    Mahar, P. D., Zubrinich, C. M., Manuelpillai, N., & Foley, P.

    Australasian Journal of Dermatology202162(4), 506–508

  44. Concurrent Use of Anifrolumab and Belimumab in a Patient With Systemic Lupus Erythematosus Presenting With Recurrent Severe Cutaneous Involvement and Lupus Nephritis

    Manjón-Rodríguez, M. D., Borrego-Utiel, F. J., Merino-García, E., Gil-Morillas, A., & Colodro-Ruiz, A.

    Cureus202517(11), e97252

  45. Dual biologics for severe asthma and atopic dermatitis: Synopsis of two cases and literature review

    Matsumoto, T., Sakurai, Y., Tashima, N., Matoba, T., Kaneko, A., Fujiki, T., Kusakabe, Y., Nakayama, E., Tanaka, A., Tashima, M., Yamamoto, N., & Aihara, K.

    Respirology Case Reports202412(1), e01266

  46. Dual Dupilumab and Omalizumab Therapy in Atopic Dermatitis, Chronic Spontaneous Urticaria and Asthma: Real-World Experience From an Eight-Patient Case Series

    McClatchy, J., Morgan, V., Scardamaglia, L., Ramirez, A., & Ross, G.

    Australasian Journal of Dermatology202667(2), 123–125

  47. Pediatric cutaneous Crohn disease: A case series of 89 patients and review

    McKay, G. E., Liu, L., Shaw, K. S., Shakshouk, H., Murphy, M. J., Damsky, W., Ortega-Loayza, A. G., Caplan, A. S., Arkin, L. M., & Shields, B. E.

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  48. Dual biologic therapy in a patient with severe psoriasis and psoriatic arthritis, using guselkumab and bimekizumab: A case report and review of the literature

    Muylaert Barrett, B., Music, M., & Yadav, G.

    SAGE Open Medical Case Reports202614, Article 2050313X251411503

  49. Is omalizumab safe and effective in oncological patients?

    Navarro-Triviño, F. J., Mérida-Fernández, C., Linares-Gonzalez, L., & Ruiz-Villaverde, R.

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  50. Off-Label Uses of Deucravacitinib for Inflammatory Skin Conditions: Cases and Literature Review

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    Case Reports in Dermatological Medicine20262026(1), Article 9941426

  51. An Unusual Case of Psoriasiform Dermatitis Treated With Dual Biologic Therapy and Literature Review

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    Olbjørn, C., Rove, J. B., & Jahnsen, J.

    Pediatric Drugs202022(4), 409–416

  53. Combined Biologic Therapy in 2 Patients With Severe Psoriasis and Severe Atopic Dermatitis

    Pascual Ares, M., Orbea Sopeña, A., Aramburu González, A., & Gardeazábal García, J.

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  54. Combining Biologics Targeting Eosinophils (IL-5/IL-5R), IgE, and IL-4/IL-13 in Allergic and Inflammatory Diseases

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  58. Combined use of Omalizumab and dupilumab: safety and efficacy data from a large academic center

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Contribute

Contribute to the Registry

Clinicians managing patients on concurrent biologic therapy are invited to contribute cases. Each submission adds to the record other clinicians can draw on.

What to Submit

  • Patient age band and biological sex
  • Biologic agents and concurrent therapy details
  • Primary diagnosis (ICD-10 coded)
  • Duration and clinical outcomes
  • Adverse events observed during treatment